The following sections explain in detail the potentially negative interactions that can occur when Zestril is combined with any of the medications listed above.
Diuretics
When taking Zestril with a diuretic, your blood pressure may decrease too much. This is more likely to occur when Zestril is first started. In order to decrease the chances of this interaction, your healthcare provider may change the dosages of either medicine, start you on a lower dose of Zestril, and/or monitor you more closely.
Nonsteroidal Anti-Inflammatory Drugs
If you have kidney disease or kidney failure, taking NSAIDs and Zestril together may add to the damage that your kidneys are already suffering. Also, NSAIDs may decrease the blood pressure-lowering effects of Zestril. Talk to your healthcare provider about using NSAIDs and Zestril together in your particular situation.
Potassium Supplements
If a potassium supplement and Zestril are taken together, the levels of potassium in your blood may become too high. This can cause serious problems. To avoid this interaction, talk to your healthcare provider about using potassium and Zestril together in your particular situation.
Potassium-Sparing Diuretics
When Zestril and a potassium-sparing diuretic are combined, your body may metabolize the drugs differently than intended and/or increase the levels of potassium in your blood. Your healthcare provider may choose to monitor your progress closely to prevent this interaction from occurring.
Lithium
If Zestril and lithium are taken together, your body may metabolize the drugs differently than intended, which can increase the levels of lithium in the blood. To prevent this interaction your healthcare provider may choose to monitor your serum lithium levels more frequently.
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