Zestril Drug Interactions

Zestril Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Zestril is combined with any of the medications listed above.
 
Aliskiren
Combining Zestril with aliskiren may increase the risk of dangerously low blood pressure (hypotension), fainting, kidney problems (including kidney failure), and dangerously high potassium levels in the blood (hyperkalemia). In general, such combinations are usually avoided. If it is necessary to take such medications together, very close monitoring will be required.
 
Zestril should never be combined with aliskiren in people with diabetes, who may have a higher risk for these complications. Also, this combination is not recommended for people with moderate-to-severe kidney problems. 
Angiotensin II Receptor Blockers (ARBs)
Combining Zestril with an ARB may increase the risk of dangerously low blood pressure (hypotension), fainting, kidney problems (including kidney failure), and dangerously high potassium levels in the blood (hyperkalemia). In general, such combinations are usually avoided. If it is necessary to take such medications together, very close monitoring will be required.
  
Diuretics
When taking Zestril with a diuretic, your blood pressure may decrease too much. This is more likely to occur when Zestril is first started. In order to decrease the chances of this interaction, your healthcare provider may change the dosages of either medicine, start you on a lower dose of Zestril, and/or monitor you more closely.
 
Nonsteroidal Anti-Inflammatory Drugs
If you have kidney disease or kidney failure, taking NSAIDs and Zestril together may add to the damage that your kidneys are already suffering. Also, NSAIDs may decrease the blood pressure-lowering effects of Zestril. Talk to your healthcare provider about using NSAIDs and Zestril together in your particular situation.
 
Potassium Supplements
If a potassium supplement and Zestril are taken together, the levels of potassium in your blood may become too high. This can cause serious problems. To avoid this interaction, talk to your healthcare provider about using potassium and Zestril together in your particular situation.
 
Potassium-Sparing Diuretics
When Zestril and a potassium-sparing diuretic are combined, your body may increase the levels of potassium in your blood. Your healthcare provider may choose to monitor your progress closely to prevent this interaction from occurring.
 
Lithium
If Zestril and lithium are taken together, your body may metabolize the drugs differently than intended, which can increase the levels of lithium in the blood. To prevent this interaction your healthcare provider may choose to monitor your serum lithium levels more frequently.
 
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Zestril (Lisinopril)

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