Drug Interactions With Valsartan

More Detail About Valsartan Interactions

The following sections explain in detail the potentially negative interactions that can occur if valsartan is combined with any of the drugs listed above.
 
Aliskiren
Combining valsartan with aliskiren may increase the risk of dangerously low blood pressure (hypotension), fainting, kidney problems (including kidney failure), and dangerously high potassium levels in the blood (hyperkalemia). In general, such combinations are usually avoided. If it is necessary to take such medications together, very close monitoring will be required.
 
Aliskiren and valsartan should never be combined in people with diabetes, because they may have a higher risk for these complications. Also, this combination is not recommended for people with moderate-to-severe kidney problems.  
 
ACE Inhibitors
Combining valsartan with an ACE inhibitor may increase the risk of dangerously low blood pressure (hypotension), fainting, kidney problems (including kidney failure), and dangerously high potassium levels in the blood (hyperkalemia). In general, such combinations are usually avoided. If it is necessary to take such medications together, very close monitoring will be required.
  
Diuretics
When taking valsartan with a diuretic, your blood pressure may decrease too much. This is more likely to occur when valsartan is first started. In order to decrease the chances of this interaction, your healthcare provider may change the dosages of either medicine, start you on a lower dose of valsartan, and/or monitor you more closely.
 
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Valsartan can interact with NSAIDs in several ways. The combination could cause your blood pressure to increase or may cause swelling (edema), especially if you have congestive heart failure (CHF). If you are elderly, have kidney disease or kidney failure, or are taking a diuretic ("water pill") or are dehydrated, taking NSAIDs and valsartan together may cause kidney failure. Talk to your healthcare provider about this potential drug interaction before taking these medications together.
  
Potassium Supplements
If you are taking a potassium supplement and valsartan, the levels of potassium in your blood may become too high. This can cause serious problems. Talk with your healthcare provider about using potassium and valsartan together.
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