Drug Interactions With Triamterene

Triamterene Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when triamterene is combined with any of the drugs listed above.
 
ACE Inhibitors
Combining triamterene with ACE inhibitors can increase the risk of high potassium levels in your blood (hyperkalemia). Your healthcare provider should check your potassium levels regularly during treatment if you are taking these medications together.
 
Amiloride
Triamterene should not be taken with amiloride. Taking these two medications together increases your risk of developing high potassium levels (hyperkalemia).
 
Angiotensin II Receptor Blockers
Taking triamterene with ARBs can increase the risk of developing high potassium levels in your blood (hyperkalemia). Your healthcare provider should check your potassium levels regularly during treatment.
 
Blood Pressure Medicine
When taking triamterene with high blood pressure medications, your blood pressure may decrease too much. In order to prevent this drug interaction from occurring, your healthcare provider may monitor you more closely and change the dose of either medicine.
 
Diabetes Medications
Because triamterene can increase blood sugar levels, your healthcare provider may need to increase your dose of insulin or oral diabetes medication.
 
Digoxin
Triamterene should be used with caution in people taking digoxin. It can cause high potassium levels (hyperkalemia), which can be especially dangerous for people taking digoxin.
 
Lithium
Taking triamterene with lithium may increase the level of lithium in your blood, possibly increasing your chance of side effects. People are typically not advised to take lithium and diuretics, including triamterene, at the same time. Depending on your individual situation, your healthcare provider may need to monitor your lithium level more closely and/or change your lithium dose.
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Triamterene Drug Information

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