Side Effects of Metolazone

Some of the potential side effects of metolazone may include dry mouth, fatigue, and headaches. In many cases, people tolerate the medication well and side effects do not often need medical attention. However, you should contact a healthcare provider immediately if you develop more serious metolazone side effects, such as fainting spells, yellowing of the skin, or a rapid heart rate.

Side Effects of Metolazone: An Overview

As with any medicine, side effects are possible with metolazone (Zaroxolyn®). However, not everyone who takes the drug will experience side effects. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or can easily be treated by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with metolazone. Your healthcare provider can discuss a more complete list of metolazone side effects with you.)

Side Effects of Metolazone to Report

Some side effects with metolazone, while occurring infrequently, are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
  • Signs of low blood pressure (hypotension), such as dizziness, lightheadedness, or fainting spells
  • Signs of dehydration or low electrolytes, such as:
    • Dry mouth
    • Thirst
    • Weakness
    • Lethargy
    • Drowsiness
    • Restlessness
    • Muscle pain or muscle cramps
    • Low blood pressure (hypotension)
    • Decreased urination
    • A rapid heart rate (tachycardia) or an irregular heart rhythm (arrhythmia)
    • Nausea or vomiting
  • High blood sugar (hyperglycemia)
  • Worsening of gout
  • Depression (see Metolazone and Depression)
  • Yellowing of the skin or whites of the eyes (jaundice)
  • Signs of an allergic reaction, such as:
    • An unexplained rash
    • Hives
    • Itching
    • Unexplained swelling
    • Wheezing
    • Difficulty breathing or swallowing.
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