Metolazone and Impotence

Clinical studies have shown that there is a likely link between metolazone and impotence. However, it is difficult to determine if the drug alone causes this or if other factors contribute to it. If you are taking metolazone and impotence becomes a problem, your healthcare provider may recommend an erectile dysfunction medication, adjust your metolazone dosage, or suggest another medication altogether.

 

Metolazone and Impotence: An Overview

Metolazone (Zaroxolyn®) may cause impotence, as is common with many blood pressure medications. In clinical studies, impotence was reported as one of the side effects of metolazone, although the exact percentage was not reported.
 

What Is Impotence?

Impotence is usually defined as a total inability to achieve an erection, an inconsistent ability to do so, or a tendency to sustain only brief erections. Ultimately, impotence is the repeated inability to get or keep an erection that is firm enough for sexual intercourse. Impotence is also known as erectile dysfunction (or ED for short).
 

Metolazone and Impotence: Final Thoughts

It is impossible for your healthcare provider to know whether you will develop impotence while taking metolazone. It may also be difficult to know whether impotence is caused by the medication alone or other problems.
 
If you are taking metolazone and impotence becomes a problem, make sure to talk with your healthcare provider. He or she may be able to recommend treatment options. Depending on the severity of your symptoms, he or she may also recommend that you take an erectile dysfunction medicine, adjust your metolazone dosage, or try another diuretic or blood pressure medication.
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;