Understanding Clinical Trials
Clinical trials are designed to factor out as many variables as possible in order to understand whether a medicine works and to determine its possible side effects. During a study, some people are given the actual medication, while others are given a placebo (which looks like the actual medication, but does not contain any of the active ingredients).
Side effects occur in people who are taking the medicine and in people who are taking a placebo. By studying both groups, it becomes easier to determine which side effects are definitely drug-related, which may be drug related, and which have nothing to do with the drug. In clinical studies, depression was reported as one of the possible metolazone side effects, although the exact percentage of people who developed depression was not reported.
Metolazone and Depression: Final Thoughts
For people taking metolazone, depression may occur. Therefore, if you notice any possible signs or symptoms of depression
while taking the drug, or if something "just does not seem right," you should talk to your healthcare provider. He or she will be able to diagnose and treat the problem. If your healthcare provider believes the medicine may be causing your symptoms, he or she may recommend another diuretic or blood pressure medicine