Drug Interactions With Metolazone

Medications such as digoxin, lithium, and NSAIDs may cause drug interactions with metolazone. These interactions can make metolazone less effective or may lead to certain side effects, such as extremely low blood pressure or low potassium levels. Prior to taking the medication, be sure to talk to your healthcare provider about any potential drug interactions with metolazone that may apply to you.

 

Drug Interactions With Metolazone: An Overview

Metolazone (Zaroxolyn®) can potentially interact with a few of other medicines. Some of the medicines that may lead to drug interactions with metolazone include:
 
  • Alcohol
  • Barbiturates, such as:
 
    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)
 
  • Other blood pressure medications
  • Corticosteroids, such as prednisone, hydrocortisone (Cortef®), dexamethasone (Decadron®, Dexone®, Hexadrol®), and many others
  • Diabetes medications, including insulin and oral diabetes medicines
  • Digoxin (Digitek®, Lanoxin®)
  • Lithium (Eskalith®, Lithobid®)
  • Loop diuretics, such as:
 
 
  • Methenamine (Hiprex®, Urex®)
  • Narcotics, such as codeine, hydrocodone, morphine, and many others
  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:
 
 
  • Salicylates, such as:
 
    • Aspirin (Ecotrin®, Bayer®, Anacin®)
    • Choline magnesium trisalicylate (Trilisate®)
    • Diflunisal (Dolobid®)
    • Salsalate (Salflex®, Disalcid®, Amigesic®)
 
  • Warfarin (Coumadin®, Jantoven®).
     
(Drug Interactions With Metolazone Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;