Drug Interactions With Metolazone

Lithium
Taking metolazone with lithium may increase the level of lithium in your blood, possibly increasing your chance of side effects. In general, people are recommended to avoid taking lithium with diuretics, including metolazone. Your healthcare provider may need to closely monitor your lithium level and/or change your lithium dosage, however, if you are taking both of these medications.
 
Loop Diuretics
Combining metolazone with a specific type of diuretic (called a "loop" diuretic) may cause dehydration or electrolyte imbalance. These medications should be used together with caution.
 
Methenamine
Methenamine can make metolazone less effective. Your healthcare provider may need to increase your metolazone dosage or recommend an alternative to methenamine.
 
Narcotics
Taking metolazone with a narcotic can increase your risk of low blood pressure, especially when sitting or standing up too fast. Talk to your healthcare provider about combining these two medications.
 
Nonsteroidal Anti-Inflammatory Drugs
Taking metolazone with NSAIDs can make metolazone less effective and may increase your risk of side effects. Your healthcare provider may need to increase your dose of metolazone or may suggest an alternative to NSAIDs.
 
Salicylates
Taking metolazone with a salicylate can increase your risk of side effects and can make metolazone less effective. Talk with your healthcare provider before combining these two medications.
 
Warfarin
Metolazone may interact with warfarin. Your healthcare provider may need to monitor you more frequently and adjust your warfarin dosage, especially when you are starting or stopping metolazone.
 
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Metolazone Drug Information

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