Metolazone Interactions Explained
The following sections explain in detail the potentially negative interactions that can occur when
metolazone is combined with any of the drugs listed above.
Alcohol
Drinking alcohol while taking metolazone can increase your risk of low
blood pressure, especially when sitting or standing up too fast. Talk to your healthcare provider about combining alcohol with metolazone.
Barbiturates
Taking metolazone with a barbiturate can increase your risk of low blood pressure, especially when sitting or standing up too fast. Talk to your healthcare provider before using barbiturates with metolazone.
Other Blood Pressure Medications
When taking metolazone with another
high blood pressure medication, your blood pressure may decrease too much. In order to reduce the chances of this drug interaction, your healthcare provider may monitor you more closely and/or change the dose of either medicine. When adding another
blood pressure medication to metolazone, your healthcare provider should generally start the other blood pressure medication at a lower dose (usually half the usual dosage).
Corticosteroids
Taking metolazone with corticosteroids may increase your risk of low potassium levels (hypokalemia) and can make metolazone less effective. Your healthcare provider should check your potassium level and may need to take steps to correct it if you are taking both of these medications.
Diabetes Medications
Because metolazone may increase blood sugar levels, your healthcare provider may need to increase your dose of insulin or oral
diabetes medication.
Digoxin
Metolazone should be used with caution in people taking digoxin. Metolazone can cause low potassium levels (hypokalemia), which can be especially dangerous for people taking digoxin.
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