Congestive Heart Failure Home > What Is Metolazone Used For?

Metolazone is used for controlling high blood pressure and treating fluid retention. The drug cannot cure these conditions, but it can help increase the amount of water and salt the kidneys remove from the blood. This decrease in blood volume can help lower blood pressure and help the body get rid of extra fluid. There are currently no off-label metolazone uses.

What Is Metolazone Used For? -- An Overview

Metolazone (Zaroxolyn®) is a prescription medication that has been licensed to treat a couple of conditions. These specific metolazone uses include:
Why Is Metolazone Used for High Blood Pressure?
A blood pressure reading consists of two numbers -- for example, 120/80. The top number is known as the systolic blood pressure, and the bottom number is the diastolic blood pressure. High blood pressure is defined as an average blood pressure higher than 140/90, with multiple blood pressure readings.
In clinical studies, metolazone has been shown to significantly lower both systolic and diastolic blood pressures. By lowering blood pressure, metolazone can decrease the risk of developing health problems, such as a stroke, heart disease, or congestive heart failure, which can occur with long-term high blood pressure (see Effects of High Blood Pressure). However, the drug is not a cure for this condition.
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Last reviewed by: Kristi Monson, PharmD;
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