Congestive Heart Failure Home > P-Glycoprotein and Digoxin

Digoxin (Lanoxin®) is prescribed to treat congestive heart failure and atrial fibrillation. Although it is an effective medication for many people, some people taking certain medications need to be aware of potential drug interactions. For example, if you take digoxin with a p-glycoprotein (Pgp) inducer or inhibitor, it can alter the way your body breaks down these medications.
P-glycoprotein is a protein found in the body that helps remove substances, such as medications, out of the body through the urine or feces. Certain medications known as Pgp inducers and Pgp inhibitors can affect the way digoxin is absorbed into the body.
Taking digoxin with a Pgp inducer can cause digoxin to be removed from the body too quickly, potentially making it less effective. A Pgp inhibitor may cause digoxin to be removed from the body more slowly, potentially increasing the amount of digoxin in your body and increasing your risk for serious side effects.
(Click Digoxin Drug Interactions for more information on what may happen if digoxin is taken with p-glycoprotein medications or certain other drugs. This article also offers a detailed list of other negative drug interactions that may occur with digoxin.)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
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