Congestive Heart Failure Home > Digoxin Drug Interactions

Several drugs can cause negative interactions with digoxin, including certain antacids, diuretics, and nonsteroidal anti-inflammatory drugs. Some of these reactions can alter the amount of the medications in the blood, possibly making them less effective or increasing your risk for side effects. Before starting treatment with digoxin, tell your healthcare provider about any other medications, herbs, or supplements you are taking.

An Overview of Interactions With Digoxin

Digoxin (Lanoxin®) may react with many other medications. Some of the drugs that can lead to digoxin interactions include but are not limited to:
  • 5-aminosalicylic acid (5-ASA) derivatives, such as:
  • Calcium salts, such as calcium chloride and calcium gluconate
  • Certain chemotherapy medications, such as:
  • Macrolide antibiotics, such as:
    • Atracurium
    • Cisatracurium (Nimbex®)
    • Pancuronium
    • Rocuronium (Zemuron®)
    • Succinylcholine (Anectine®, Quelicin®)
    • Vecuronium (Norcuron®)
  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:
  • P-glycoprotein inducers, such as:
  • P-glycoprotein inhibitors, such as:
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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