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While a link between depression and captopril is suspected, the side effect is so rare that it is difficult to determine whether it is caused by the medicine itself or by other factors. Signs that may indicate depression include a persistent sad mood, difficulty concentrating, or thoughts of suicide. If you experience depression and captopril is a medication you are on, your healthcare provider may recommend other medications.

Depression and Captopril: An Overview

There are several possible side effects for people taking captopril (available as Capoten® and generic captopril). Depression appears to be a rare complaint in people taking the drug. In clinical studies, depression was reported in less than 1 percent of people who took the medicine. Given how common depression is in the general population and how rare a complaint it is in people who take captopril, it is difficult to determine whether depression is actually caused by the medicine itself, by other specific factors, or by a combination of factors.

Depression and Captopril: What to Look For

While depression may not be a commonly reported side effect of captopril, it is extremely common in society today. In fact, in any given one-year period, 9.5 percent of the population (about 18.8 million American adults) suffer from depression. Therefore, knowing the symptoms of depression can be helpful.
Possible symptoms of depression may include:
  • Persistent sad, anxious, or "empty" mood
  • Feelings of hopelessness and pessimism
  • Feelings of guilt, worthlessness, and helplessness
  • Loss of interest or pleasure in hobbies and activities that were once enjoyed, including sex
  • Decreased energy, fatigue, and being "slowed down"
  • Difficulty concentrating, remembering, and making decisions
  • Insomnia, early-morning awakening, or oversleeping
  • Appetite and/or weight loss or overeating and weight gain
  • Thoughts of death or suicide, suicide attempts
  • Restlessness and irritability
  • Persistent physical symptoms that do not respond to treatment, such as headaches, digestive disorders, and chronic pain.
Keep in mind that there are other conditions that can share similar symptoms with depression.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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