Congestive Heart Failure Home > Warnings and Precautions With Amiloride-HCTZ

To ensure a safe treatment process, it is important to be aware of the warnings and precautions with amiloride-HCTZ. For example, the drug can cause changes in your potassium levels, which can be very dangerous. Warnings and precautions with amiloride-HCTZ also extend to those with kidney disease, already-high potassium levels, or allergies to sulfonamides ("sulfa drugs").

Amiloride-HCTZ: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking amiloride-HCTZ (Moduretic®) if you have:
  • Liver disease, including cirrhosis
  • Asthma
  • Kidney disease or kidney failure
  • Diabetes
  • Fluid or electrolyte problems
  • Any allergies, including allergies to sulfa drugs, foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or trying to become pregnant
  • Breastfeeding.
Tell your healthcare provider about all the medicines you are currently taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Warnings and Precautions With Amiloride-HCTZ

Warnings and precautions to be aware of prior to taking amiloride-HCTZ include the following:
  • The medication can cause low potassium levels (hypokalemia) or high potassium levels (hyperkalemia). If you notice any symptoms of a possible electrolyte imbalance, contact your healthcare provider. These symptoms may include:
o Dry mouth
o Thirst
o Weakness
o Lethargy
o Drowsiness
o Restlessness
o Muscle pain or muscle cramps
o Low blood pressure (hypotension)
o Decreased urination
o Rapid heart rate (tachycardia) or irregular heart rhythm (arrhythmia)
o Nausea or vomiting.
Changes in potassium levels can be dangerous. Because symptoms are not always present, your healthcare provider should measure your potassium levels regularly during treatment using a simple blood test.
  • In general, people with diabetes should not take amiloride-HCTZ, as they may be at higher risk for high potassium levels.
  • The medication should be started cautiously in people with liver disease, as it may increase the risk of hepatic encephalopathy (a brain problem in people with liver disease).
  • Amiloride-HCTZ may cause gout or make it worse in people who already have it. Make sure to tell your healthcare provider if you have this condition or if it is becoming worse.
  • Do not use salt substitutes while taking amiloride-HCTZ. Salt substitutes usually contain potassium, and combining them with amiloride-HCTZ can increase the risk of high potassium levels in your blood (hyperkalemia). Herb-type salt substitutes that do not contain potassium are okay to use.
  • If you have asthma, you may be more likely to be allergic to amiloride-HCTZ.
  • Amiloride-HCTZ can interact with several medications (see Drug Interactions With Amiloride-HCTZ).
  • Amiloride-HCTZ is considered a pregnancy Category B medication. This means that it may be safe to use during pregnancy, although the full risks are not known. Talk to your healthcare provider about the risks and benefits of using the drug while pregnant (see Moduretic and Pregnancy).
  • It is not known if amiloride-HCTZ passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider before taking the drug (see Moduretic and Breastfeeding).
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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