Congestive Heart Failure Home > Drug Interactions With Amiloride-HCTZ

When certain medications are combined, there is a possibility for negative drug interactions. With amiloride-HCTZ, these interactions can lead to high potassium levels, low blood pressure, and decreased effectiveness. Alcohol, Celebrex, and Luminal are among the substances that can interact with amiloride-HCTZ. In order to reduce the risk of drug interactions with amiloride-HCTZ, your healthcare provider may monitor you more closely and adjust your dosages.

Drug Interactions With Amiloride-HCTZ: An Overview

Amiloride-HCTZ (Moduretic®) can potentially interact with a number of other medicines. Some of the medications that can cause amiloride-HCTZ drug interactions include:
  • ACE inhibitors, including:



  • Alcohol 
  • Angiotensin II receptor blockers (ARBs), such as:


  • Barbiturates, including:


    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)




  • Potassium-containing products, such as:


    • Potassium chloride (K-Dur®, Klor-Con®, Micro-K®)
    • Potassium citrate (Urocit-K®, Polycitra-K®)
    • Potassium gluconate
    • Potassium phosphate (Neutra-Phos-K®, K-Phos®)
    • Salt substitutes (used to flavor food)


Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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