Congestive Heart Failure Home > Aldactone Drug Interactions

Digoxin (Digitek, Lanoxin)
Aldactone should be used carefully in people taking digoxin, as Aldactone can cause high potassium levels (hyperkalemia), which can be especially dangerous for people taking digoxin. Aldactone can also increase the level of digoxin in your blood.
 
Eplerenone (Inspra)
Aldactone should not be combined with eplerenone, due to the high risk for dangerously high blood potassium levels (hyperkalemia).
 
Heparin
Combining Aldactone with heparin or low molecular weight heparin medications can increase the risk of high potassium levels in your blood (hyperkalemia). Your healthcare provider should check your potassium levels regularly if you are taking both of these medications.
 
Lithium (Eskalith, Lithobid)
Taking Aldactone with lithium may increase the level of lithium in your blood, increasing your chance of side effects. In general, lithium is usually not recommended to be taken with diuretics, including Aldactone. Your healthcare provider may need to monitor your lithium level more closely and change your lithium dose.
 
Narcotics
Taking Aldactone with a narcotic can increase your risk of low blood pressure, especially when sitting or standing up suddenly. Talk to your healthcare provider about combining narcotics with Aldactone.
 
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Taking Aldactone with NSAIDs can make Aldactone less effective and may increase your risk of side effects (including high potassium levels in your blood). Your healthcare provider may need to increase your dose of Aldactone or suggest an alternative to NSAIDs.
 
Potassium
In general, potassium-containing products should not be used with Aldactone, due to the risk of high potassium levels (hyperkalemia).
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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