Congestive Heart Failure Home > Aldactazide Drug Interactions

When certain medicines, such as barbiturates, amiloride, or ACE inhibitors, are taken with Aldactazide, drug interactions may occur. Some interactions can cause your blood pressure to decrease too much, while others can lead to high potassium levels in your blood. Other medicines that may cause negative Aldactazide drug interactions include triamterene, nonsteroidal anti-inflammatory drugs, angiotensin II receptor blockers, and diabetes medications.

An Overview of Aldactazide Drug Interactions

Aldactazide® (spironolactone-HCTZ) can potentially interact with a number of other medicines. Some of the medicines that can cause Aldactazide drug interactions include:


  • Barbiturates, such as:
    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)
  • Potassium-containing products, such as:
    • Potassium chloride (K-Dur®, Klor-Con®, Micro-K®)
    • Potassium citrate (Urocit-K®, Polycitra-K®)
    • Potassium gluconate
    • Potassium phosphate (Neutra-Phos-K®, K-Phos®)
    • Salt substitutes (used to flavor food)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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