Edecrin Warnings and Precautions

It's important to be aware of Edecrin warnings and precautions before starting treatment, including the potential for serious side effects. The diuretic may cause hearing loss, extremely low blood pressure, and an electrolyte imbalance. Edecrin warnings and precautions also extend to those who are allergic to any components of the medicine, are producing very little or no urine, or experience severe diarrhea or worsened kidney function while taking it.

Edecrin: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking Edecrin® (ethacrynic acid) if you have:
  • Liver disease, including cirrhosis
  • Kidney disease or kidney failure (renal failure)
  • Diabetes
  • Gout
  • Fluid or electrolyte problems
  • Any allergies, including allergies to sulfa drugs, foods, dyes, or preservatives.
Also, let your healthcare provider know if you:
Tell your healthcare provider about all other medicines you are currently taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Edecrin Warnings and Precautions

Precautions and warnings to be aware of prior to taking Edecrin include the following:
  • Edecrin is a potent diuretic with the potential to cause too much water and electrolyte loss. Your healthcare provider should carefully monitor you while you are taking the drug. This involves monitoring your weight (usually on a daily basis) and checking your electrolyte levels (using a blood test).
  • If kidney problems seem to be getting worse (especially for those with severe kidney disease), the medication should be stopped, since it can sometimes make kidney problems worse.
  • Edecrin should be used with caution in people with cirrhosis or other liver problems. Electrolyte changes (which are common with the drug) can be dangerous in people with liver disease.
  • Edecrin can cause hearing loss. Sometimes, this hearing loss is permanent. It is more common when high doses of the drug are given intravenously or when combined with other medications that can cause hearing loss. Let your healthcare provider know right away if you notice hearing loss or ringing in the ears (tinnitus).
  • Edecrin can interact with certain medications (see Edecrin Drug Interactions).
  • The medication may cause extreme low blood pressure in some people. This is more likely to happen when the medicine is first started or if the dosage is changed. It is also more likely to happen in people who:
This is why it is important to drink fluids regularly while taking the drug. If you have any possible symptoms of low blood pressure, such as dizziness, lightheadedness, or fainting, contact your healthcare provider. If you have fainted, stop taking Edecrin until you have talked to your healthcare provider.
Also, make sure not to drive, operate any heavy machinery, or perform any other tasks that require alertness until you know how Edecrin affects you.
  • The medication may affect electrolytes in the blood (including sodium, calcium, potassium, magnesium, and chloride). Therefore, your healthcare provider will regularly check these levels. If you notice any symptoms of a possible electrolyte imbalance, contact your healthcare provider. These symptoms may include:
    • Dry mouth
    • Thirst
    • Weakness
    • Lethargy
    • Drowsiness
    • Restlessness
    • Muscle pain or muscle cramps
    • Low blood pressure (hypotension)
    • Decreased urination
    • Rapid heart rate (tachycardia) or irregular heart rhythm (arrhythmia)
    • Nausea or vomiting.
  • Edecrin is also known to make gout worse.
  • Edecrin is considered a pregnancy Category B medication. This means that it is probably safe for use during pregnancy, although the full risks are not known. Talk to your healthcare provider about the risks and benefits of using the drug during pregnancy (see Edecrin and Pregnancy).
  • It is not known if Edecrin passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider before taking the drug (see Edecrin and Breastfeeding).
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Edecrin Drug Information

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