Dyazide Drug Interactions

Digoxin
Dyazide should be used with caution in people taking digoxin. It can cause low potassium levels (hypokalemia) or high potassium levels (hyperkalemia), both of which can be especially dangerous for people taking digoxin.
 
Laxatives
Dyazide may be less effective in people who overuse laxatives (or who use laxatives chronically). Ask your healthcare provider about using laxatives on a regular basis while taking Dyazide.
 
Lithium
Taking Dyazide with lithium may raise the level of lithium in your blood, potentially increasing your chances of side effects. In general, it is not recommended that you take lithium with diuretics, including Dyazide. If you are taking these drugs together, your healthcare provider may need to monitor your lithium level more closely and/or change your lithium dose to prevent a drug interaction from occurring.
 
Nonsteroidal Anti-Inflammatory Drugs
Taking Dyazide with nonsteroidal anti-inflammatory drugs (NSAIDs) can make Dyazide less effective and may increase your risk of side effects. Depending on your situation, your healthcare provider may need to increase your dose of Dyazide or may suggest an alternative to NSAIDs.
 
Methenamine
Taking methenamine with Dyazide may make methenamine less effective. Talk with your healthcare provider about taking these medications together.
 
Potassium-Containing Products
In general, products containing potassium should not be used with Dyazide, due to the risk of high potassium levels (hyperkalemia).
 
Spironolactone
Dyazide should not be taken with spironolactone. Taking these two medications together increases your risk of high potassium levels (hyperkalemia).
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Dyazide Drug Information

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