Digoxin Drug Interactions

Conivaptan
Conivaptan may increase digoxin blood levels, increasing your risk for serious side effects. Your healthcare provider may decide to monitor your digoxin levels with a simple blood test if you take these medications together, especially when you start or stop taking conivaptan.
 
Diuretics
Some diuretics decrease blood potassium levels. Taking any of these diuretics with digoxin increases your risk for digoxin toxicity. In addition, spironolactone may increase digoxin blood levels. Your healthcare provider may choose to monitor your potassium and digoxin levels with a simple blood test if you take digoxin with any of these diuretics.
 
Macrolide Antibiotics
Macrolide antibiotics may increase the amount of digoxin absorbed into the body, potentially increasing your risk for serious side effects. Older adults may have an increased risk for this interaction. Your healthcare provider may choose to monitor your digoxin levels with a simple blood test when you start or stop a macrolide antibiotic.
 
Metoclopramide
Metoclopramide may decrease the amount of digoxin absorbed into the body, potentially making it less effective. Your healthcare provider may want to monitor your digoxin levels with a simple blood test when you start or stop metoclopramide.
 
Midodrine
Combining midodrine with digoxin may increase your risk for an extremely slow heart rate. Your healthcare provider may want to monitor your heart rate more closely if you take these medications together.
 
Milnacipran
There are reports of increased heart rate and low blood pressure when milnacipran was combined with digoxin. This interaction is likely only a concern when digoxin is given via intravenous (IV) injection.
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Digoxin Drug Information

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