Digoxin Drug Interactions

Calcitriol
Taking digoxin with calcitriol may increase your risk for serious digoxin side effects. Talk to your healthcare provider before taking these medications together.
 
Calcium Channel Blockers
Combining a calcium channel blocker with digoxin may increase your risk for serious side effects. In addition, certain calcium channel blockers (diltiazem and verapamil) may increase digoxin blood levels. Your healthcare provider may decide to monitor you more closely if you take digoxin and a calcium channel blocker.
 
Calcium Salts
Combining digoxin with calcium salts increases the risk for serious arrhythmias. This interaction is mostly a concern when calcium is given intravenously (by IV). However, it is still a good idea to let your healthcare provider know if you are taking any products that contain calcium.
 
Chemotherapy Medications
Certain chemotherapy medications may decrease the amount of digoxin absorbed into the body, potentially making it less effective. This interaction only occurs with digoxin tablets. Your healthcare provider may want to monitor your digoxin levels with a simple blood test, especially when you start or stop chemotherapy.
 
Cholestyramine
Cholestyramine may bind to digoxin in the stomach, decreasing the amount of digoxin absorbed into the body. Separating the doses of the medications by two or more hours may reduce the risk of this interaction, but will likely not completely eliminate it. Talk to your healthcare provider before taking digoxin with cholestyramine.
 
Colchicine
Digoxin may increase the levels of colchicine in the body, increasing your risk for serious colchicine side effects. There have been reports of muscle damage, including a serious condition involving muscle fiber breakdown (rhabdomyolysis) when these medications were taken together. Talk to your healthcare provider before taking digoxin with colchicine.
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Digoxin Drug Information

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