Digoxin Drug Interactions

More Detail on Digoxin Drug Interactions

The following sections explain in detail the potentially negative reactions that can occur when digoxin is combined with any of the drugs listed above.
 
5-Aminosalicylic Acid (5-ASA) Derivatives
5-ASA derivative medications may decrease the absorption of digoxin into the body, decreasing digoxin blood levels. This could make digoxin less effective. Your healthcare provider may want to monitor your digoxin levels with a simple blood test, especially when you start or stop taking a 5-ASA derivative medication.
 
Acarbose
Acarbose may decrease digoxin blood levels, which could make it less effective. Talk to your healthcare provider before taking these medications together. He or she may want to monitor your digoxin levels with a simple blood test, especially when you start or stop taking acarbose.
 
Amiodarone
Amiodarone may increase the levels of digoxin in the body, increasing your risk for serious side effects. Your healthcare provider may decrease your digoxin dose when you start amiodarone, and monitor your digoxin levels with a blood test. Children may have a greater risk for this interaction.
 
Antacids
Antacids may decrease the absorption of digoxin into the body, potentially making it less effective. Talk to your healthcare provider before taking antacids with digoxin.
 
Beta Blockers
Taking beta blockers with digoxin increases your risk for a very slow heart rate (bradycardia). This interaction is less of a concern with beta blocker eye drops. In addition, carvedilol (Coreg) may increase digoxin levels in the body, increasing your risk for serious side effects. Talk to your healthcare provider before taking a beta blocker with digoxin.
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Digoxin Drug Information

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