Drug Interactions With Chlorthalidone

Drug interactions with chlorthalidone are possible if it is combined with medications such as barbiturates, corticosteroids, narcotics, or alcohol. These interactions can increase your risk of certain side effects, such as low blood pressure, and may decrease the effectiveness of some drugs. If drug interactions with chlorthalidone are a concern, your healthcare provider may choose to adjust your dosages.

 

An Overview of Drug Interaction With Chlorthalidone

Chlorthalidone (Thalitone®) can potentially interact with a number of other medicines. Some of the medicines that can lead to chlorthalidone drug interactions include:
 
  • Alcohol
     
  • Barbiturates, including:
     
    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)
 
  • Other blood pressure medicines
     
  • Corticosteroids, such as:
     
    • Prednisone
    • Hydrocortisone (Cortef®)
    • Dexamethasone (Decadron®, Dexone®, Hexadrol®)
 
  • Diabetes medications, including insulin and oral diabetes medicines
     
  • Digoxin (Digitek®, Lanoxin®)
     
  • Lithium (Eskalith®, Lithobid®)
     
  • Narcotics, such as:
     
    • Codeine
    • Hydrocodone
    • Morphine
 
 
  • Salicylates, such as:
     
    • Aspirin (Ecotrin®, Bayer®, Anacin®)
    • Choline magnesium trisalicylate (Trilisate®)
    • Diflunisal (Dolobid®)
    • Salsalate (Salflex®, Disalcid®, Amigesic®).
 
(Drug Interactions With Chlorthalidone Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;