Drug Interactions With Chlorthalidone (Cont.)

 
Lithium
Taking chlorthalidone with lithium may raise the level of lithium in your blood, increasing your chances of side effects. In general, it is not recommended that lithium be taken with diuretics, including chlorthalidone. Depending on your individual situation, your healthcare provider may need to monitor your lithium level more closely and/or change your lithium dose.
 
Narcotics
Combining chlorthalidone with a narcotic can increase your risk of low blood pressure, especially when sitting or standing up suddenly. Talk with your healthcare provider about taking these medications together.
 
Nonsteroidal Anti-Inflammatory Drugs
Taking chlorthalidone with nonsteroidal anti-inflammatory drugs (NSAIDs) can make chlorthalidone less effective and may increase your risk of chlorthalidone side effects. To prevent this interaction from occurring, your healthcare provider may need to increase your dose of chlorthalidone or may suggest an alternative to NSAIDs.
 
Salicylates
Taking chlorthalidone with a salicylate can increase your risk of side effects and can make chlorthalidone less effective. Talk with your healthcare provider before combining these medications.
 

Final Thoughts on Drug Interactions With Chlorthalidone

It is possible that not all drug interactions with chlorthalidone were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about the specific interactions that may apply to you.

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;