Drug Interactions With Chlorthalidone (Cont.)

Chlorthalidone Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when chlorthalidone is combined with any of the drugs listed above.
 
Alcohol
Drinking alcohol while taking chlorthalidone can increase your risk of low blood pressure, especially when sitting or standing up suddenly. Talk with your healthcare provider about combining alcohol with chlorthalidone.
 
Barbiturates
Taking chlorthalidone with a barbiturate can increase your risk of low blood pressure, especially when sitting or standing up suddenly. Talk with your healthcare provider before combining these medications.
 
Other Blood Pressure Medicines
When taking chlorthalidone with another high blood pressure medication, your blood pressure may decrease too much. In order to decrease the chances of this chlorthalidone interaction, your healthcare provider may monitor you more closely and/or change the dose of either medicine.
 
Corticosteroids
Taking chlorthalidone with corticosteroids may increase your risk of low potassium levels (hypokalemia). If you are taking these drugs together, your healthcare provider should check your potassium levels. He or she may also need to take steps to correct it, if needed.
 
Diabetes Medications
Because chlorthalidone may increase blood sugar levels, your healthcare provider may need to increase your dose of insulin or oral diabetes medication to prevent interactions with chlorthalidone from occurring.
 
Digoxin
Chlorthalidone should be used with caution in people taking digoxin. The medication can cause low potassium levels (hypokalemia), which can be especially dangerous for people taking digoxin.
(Drug Interactions With Chlorthalidone Continued: Page 3)

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;