Chlorthalidone Dosing

Chlorthalidone dosing guidelines take various factors into account, such as the condition being treated, other conditions a person may have, and how he or she responds to chlorthalidone. When used to treat high blood pressure, the starting chlorthalidone dosage is usually 25 mg a day. When treating water retention, the starting dose is 50 mg to 100 mg. To ensure a successful treatment process, it's best to take your chlorthalidone dose as prescribed.

An Overview of Chlorthalidone Dosing

The dose of chlorthalidone (Thalitone®) that your healthcare provider recommends will vary depending on a number of factors, including:
  • Other medical conditions you may have
  • Other medications you may be currently taking
  • How you respond to chlorthalidone.
As always, do not adjust your chlorthalidone dosage unless your healthcare provider specifically instructs you to do so.

Chlorthalidone Dosing for High Blood Pressure

The recommended starting chlorthalidone dose for high blood pressure is chlorthalidone 25 mg, taken once daily. Based on the initial blood pressure response and/or chlorthalidone side effects, your healthcare provider may increase or decrease your dose if necessary. With each change in dosage, it may take several weeks to see the full effects of chlorthalidone on lowering blood pressure.
Because brand-name Thalitone is more potent than generic chlorthalidone, a lower starting dose is usually recommended -- Thalitone 15 mg a day.

Chlorthalidone Dosing for Water Retention

The recommended starting dose of chlorthalidone for fluid retention (edema) is chlorthalidone 50 mg to 100 mg once daily (or 100 mg every other day). Some people need to take the medication only when they need it (for example, when they are experiencing water retention). Others need to take it on a daily basis.
Because brand-name Thalitone is more potent that generic chlorthalidone, a lower starting dose is typically recommended -- Thalitone 30 mg to 60 mg once daily (or 60 mg every other day).
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Chlorthalidone Drug Information

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