Drug Interactions With Chlorothiazide

When various medications are taken together, it is possible to develop negative drug interactions. With chlorothiazide, medications that may cause an interaction include lithium, nonsteroidal anti-inflammatory drugs, narcotics, and diabetes medicines. Chlorothiazide drug interactions may increase your risk of developing potentially serious side effects or reduce the effectiveness of the medications.

 

Chlorothiazide Drug Interactions: An Overview

Chlorothiazide (Diuril®) can potentially interact with a number of other medicines. Some of these medicines that can lead to chlorothiazide interactions include:
 
  • Alcohol
  • Barbiturates, including:
o Amobarbital (Amytal®)
o Butalbital (Fioricet®, Fiorinal®)
o Pentobarbital (Nembutal®)
o Phenobarbital (Luminal®)
o Secobarbital (Seconal®)
o Diclofenac (Cataflam®, Voltaren®)
o Ibuprofen (Motrin®, Advil®)
o Indomethacin (Indocin®, Indocin SR®)
  • Salicylates, such as aspirin (Ecotrin®, Bayer®, Anacin®), choline magnesium trisalicylate (Trilisate®), diflunisal (Dolobid®), and salsalate (Salflex®, Disalcid®, Amigesic®).
     
(Drug Interactions With Chlorothiazide Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;