Drug Interactions With Chlorothiazide

When various medications are taken together, it is possible to develop negative drug interactions. With chlorothiazide, medications that may cause an interaction include lithium, nonsteroidal anti-inflammatory drugs, narcotics, and diabetes medicines. Chlorothiazide drug interactions may increase your risk of developing potentially serious side effects or reduce the effectiveness of the medications.

Chlorothiazide Drug Information

Chlorothiazide Drug Interactions: An Overview

Chlorothiazide (Diuril^®) can potentially interact with a number of other medicines. Some of these medicines that can lead to chlorothiazide interactions include:

Alcohol
Barbiturates, including:

o Amobarbital (Amytal^®)

o Butalbital (Fioricet^®, Fiorinal^®)

o Pentobarbital (Nembutal^®)

o Phenobarbital (Luminal^®)

o Secobarbital (Seconal^®)

Other blood pressure medicine
Cholestyramine (Prevalite^®, Questran^®, Questran Light^®)
Colestipol (Colestid^®)
Corticosteroids, such as prednisone, hydrocortisone (Cortef^®), dexamethasone (Decadron^®, Dexone^®, Hexadrol^®), and many others
Diabetes medications, including insulin and oral diabetes medicines
Digoxin (Digitek^®, Lanoxin^®)
Lithium (Eskalith^®, Lithobid^®)
Narcotics, such as codeine, hydrocodone, morphine, and many others
Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:

o Celecoxib (Celebrex^®)

o Diclofenac (Cataflam^®, Voltaren^®)

o Etodolac (Lodine^®)

o Ibuprofen (Motrin^®, Advil^®)

o Indomethacin (Indocin^®, Indocin SR^®)

o Ketoprofen

o Ketorolac (Toradol^®)

o Meloxicam (Mobic^®)

o Naproxen (Naprosyn^®) or naproxen sodium (Aleve^®, Anaprox^®, Naprelan^®)

o Nabumetone (Relafen^®)

o Oxaprozin (Daypro^®)

Salicylates, such as aspirin (Ecotrin^®, Bayer^®, Anacin^®), choline magnesium trisalicylate (Trilisate^®), diflunisal (Dolobid^®), and salsalate (Salflex^®, Disalcid^®, Amigesic^®).

(Drug Interactions With Chlorothiazide Continued: Page 2)