Drug Interactions With Chlorothiazide
When various medications are taken together, it is possible to develop negative drug interactions. With chlorothiazide, medications that may cause an interaction include lithium, nonsteroidal anti-inflammatory drugs, narcotics, and diabetes medicines. Chlorothiazide drug interactions may increase your risk of developing potentially serious side effects or reduce the effectiveness of the medications.
Chlorothiazide (Diuril®) can potentially interact with a number of other medicines. Some of these medicines that can lead to chlorothiazide interactions include:
- Barbiturates, including:
o Amobarbital (Amytal®)o Butalbital (Fioricet®, Fiorinal®)o Pentobarbital (Nembutal®)o Phenobarbital (Luminal®)o Secobarbital (Seconal®)
- Other blood pressure medicine
- Cholestyramine (Prevalite®, Questran®, Questran Light®)
- Colestipol (Colestid®)
- Corticosteroids, such as prednisone, hydrocortisone (Cortef®), dexamethasone (Decadron®, Dexone®, Hexadrol®), and many others
- Diabetes medications, including insulin and oral diabetes medicines
- Digoxin (Digitek®, Lanoxin®)
- Lithium (Eskalith®, Lithobid®)
- Narcotics, such as codeine, hydrocodone, morphine, and many others
- Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:
- Salicylates, such as aspirin (Ecotrin®, Bayer®, Anacin®), choline magnesium trisalicylate (Trilisate®), diflunisal (Dolobid®), and salsalate (Salflex®, Disalcid®, Amigesic®).