Drug Interactions With Chlorothiazide (Cont.)

 
Diabetes Medications
Because chlorothiazide may increase blood sugar levels, your healthcare provider may need to increase your dose of insulin or oral diabetes medication.
 
Digoxin (Digitek, Lanoxin)
Chlorothiazide should be used carefully in people taking digoxin. Chlorothiazide can cause low potassium levels (hypokalemia), which can be especially dangerous for people taking digoxin.
 
Lithium (Eskalith, Lithobid)
Taking chlorothiazide with lithium may increase the level of lithium in your blood, increasing your chance of side effects. Generally, it is usually not recommended to take lithium with diuretics, including chlorothiazide. Your healthcare provider may need to monitor your lithium level more closely and change your lithium dose.
 
Narcotics
Taking chlorothiazide with a narcotic can increase your risk of low blood pressure, especially when sitting or standing up suddenly. Talk to your healthcare provider about combining narcotics with chlorothiazide.
 
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Taking chlorothiazide with NSAIDs can make chlorothiazide less effective and may increase your risk of side effects. Your healthcare provider may need to increase your dose of chlorothiazide or may suggest an alternative to NSAIDs.
 
Salicylates
Taking chlorothiazide with a salicylate can increase your risk of side effects and can make chlorothiazide less effective. Talk with your healthcare provider before combining chlorothiazide with salicylates.
 

Final Thoughts on Chlorothiazide Drug Interactions

It is possible that not every chlorothiazide drug interaction was discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about specific drug interactions with chlorothiazide that may apply to your situation.
 

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;