Chlorothiazide Interactions Explained
The following sections explain in detail the potentially negative interactions that can occur when
chlorothiazide is combined with any of the drugs listed above.
Alcohol
Drinking alcohol while taking chlorothiazide can increase your risk of low
blood pressure, especially when sitting or standing up suddenly. Talk to your healthcare provider about combining alcohol with chlorothiazide.
Barbiturates
Taking chlorothiazide with a barbiturate can increase your risk of low blood pressure, especially when sitting or standing up suddenly. Talk to your healthcare provider before using barbiturates with chlorothiazide.
Other Blood Pressure Medicine
When taking chlorothiazide with another
high blood pressure medication, your blood pressure may decrease too much. In order to reduce the chances of this chlorothiazide interaction, your healthcare provider may monitor you more closely and/or change the dose of either medicine.
Cholestyramine (Prevalite, Questran, Questran Light)
Cholestyramine can decrease the absorption of chlorothiazide into your blood, perhaps making it less effective. In order to avoid this interaction, it is usually best to take these medications at different times of the day.
Colestipol (Colestid)
Colestipol can decrease the absorption of chlorothiazide into your blood, perhaps making it less effective. In order to avoid this interaction, it is usually best to take these medications at different times of the day.
Corticosteroids
Taking chlorothiazide with corticosteroids may increase your risk of low potassium levels (hypokalemia). Your healthcare provider should check your potassium levels and may need to take steps to correct your potassium level.
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