Chlorothiazide Overdose

Increased thirst, lightheadedness, and loss of consciousness are symptoms that may occur when a person overdoses on chlorothiazide. Overdose effects may also include low electrolytes, dehydration, and irregular heart rhythm. There are various treatment options available for a chlorothiazide overdose, including certain medicines, supportive care, and "pumping the stomach."

 

Chlorothiazide Overdose: An Overview

Chlorothiazide (Diuril®) is a medication that is used for controlling high blood pressure and treating water retention (edema). The effects of a chlorothiazide will vary depending on a number of factors, including how much chlorothiazide was taken and whether it was taken with any other medicines, alcohol, and/or drugs.
 
If you happen to overdose on chlorothiazide, seek medical attention immediately.
 

Symptoms of a Chlorothiazide Overdose

The effects of a chlorothiazide overdose may include:
 
  • Dehydration
  • Low electrolytes (especially low potassium, chloride, and sodium)
  • Irregular heart rhythm (arrhythmia), especially in people taking dixogin (Digitek®, Lanoxin®).
     
This may cause signs or symptoms that include:
 
  • Lightheadedness, dizziness, or fainting
  • Decrease in urine output
  • Drowsiness, headache, or back pain
  • Slow or irregular heartbeat
  • Dry mouth
  • Increased thirst
  • Weakness
  • Tiredness
  • Restlessness
  • Seizures
  • Confusion
  • Muscle pain or cramps
  • Nausea or vomiting
  • Loss of consciousness.
     
(Chlorothiazide Overdose Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;