For adults who are first starting chlorothiazide, dosing typically starts at 500 to 1000 mg daily, taken in one dose or split into two doses each day. The recommended dosage for children is 5 to 10 mg per pound of weight daily. Chlorothiazide dosing for children shouldn't exceed 375 mg (for those under 2 years old) or 1000 mg daily (for those 2 to 12 years old).
The dose of chlorothiazide (Diuril®) that your healthcare provider recommends will vary depending on a number of factors, including:
- Other medical conditions you may have
- Other medications you may currently be taking
- How you respond to chlorothiazide.
As is always the case, do not adjust your dose unless your healthcare provider specifically instructs you to do so.
Chlorothiazide Dosing for Adults
The recommended starting chlorothiazide dose for high blood pressure or water retention is 500 to 1000 mg, taken either once a day or split up into two doses per day. Based on the initial blood pressure response and side effects of chlorothiazide, your healthcare provider may increase (or decrease) your dose if necessary. With each change in dosage, it may take several weeks to see the full blood pressure-lowering effects of chlorothiazide.
People taking chlorothiazide for water retention may not need to take it every day. Some people take the drug every other day (or even less frequently).
Chlorothiazide Dosing for Infants and Children
The recommended chlorothiazide dose for children and infants depends on the age and weight of the child. The recommended dose of chlorothiazide is 5 to 10 mg per pound of body weight each day (either taken in one daily dose or two smaller doses per day). Infants younger than six months old may need a higher dose (chlorothiazide 15 mg per pound per day). The maximum chlorothiazide dosage is 375 mg per day (for those 2 years old or younger) or 1000 mg per day (for children 2 to 12 years old).