Drug Interactions With Carvedilol

Diphenhydramine
If you are taking carvedilol and diphenhydramine together, your body may metabolize carvedilol differently than intended. This can increase the level of carvedilol in your body. If you are using these medicines together, your healthcare provider may choose to monitor you more closely and/or adjust your carvedilol dose if needed.
 
Hydroxychloroquine
If you are taking carvedilol and hydroxychloroquine together, your body may metabolize carvedilol differently than intended. This can cause an increased level of carvedilol in your body. If you are using these medicines together, your healthcare provider may choose to monitor you more closely and/or adjust your carvedilol dose if needed.
 
Monoamine Oxidase Inhibitors (MAOIs)
Combining carvedilol with an MAOI may increase the risk of low blood pressure or a slow heart rate. Check with your healthcare provider before taking such medications together.
 
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
NSAIDs may decrease the blood pressure-lowering effects of carvedilol. Talk with your healthcare provider about using NSAIDs and carvedilol together in your particular situation.
 
Other Beta Blockers
Carvedilol is a beta blocker and should not be combined with other beta blockers, as this may increase the risk of serious side effects.
 
Reserpine
Combining reserpine with a beta blocker can increase the risk of serious side effects. You may need to be monitored closely if you take these medications together. In some cases, it is not recommended to combine carvedilol with reserpine.
 
Rifampin
Rifampin can drastically decrease the level of carvedilol in the blood, making it less effective. Check with your healthcare provider before taking these medications together.
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