Drug Interactions With Captopril

More Information on Captopril Drug Interactions

The following sections explain in detail the potentially negative interactions that can occur when captopril is combined with any of the drugs listed above.
 
Aliskiren
Combining captopril with aliskiren may increase the risk of dangerously low blood pressure (hypotension), fainting, kidney problems (including kidney failure), and dangerously high potassium levels in the blood (hyperkalemia). In general, such combinations are usually avoided. If it is necessary to take such medications together, very close monitoring will be required.
 
Aliskiren and captopril should never be combined in people with diabetes, because they may have a higher risk for these complications. Also, this combination is not recommended for people with moderate-to-severe kidney problems.
 
Angiotensin II Receptor Blockers (ARBs)
Combining captopril with an ARB may increase the risk of dangerously low blood pressure (hypotension), fainting, kidney problems (including kidney failure), and dangerously high potassium levels in the blood (hyperkalemia). In general, such combinations are usually avoided. If it is necessary to take such medications together, very close monitoring will be required.
  
Diuretics
When taking captopril with a diuretic, your blood pressure may decrease too much. This is more likely to occur when captopril is first started. In order to decrease the chances of this interaction, your healthcare provider may change the dosage of either medicine, start you on a lower dose of captopril, and/or monitor you more closely.
 
Injectable Gold
Reactions have been reported in people taking captopril who received gold injections. These reactions included symptoms such as facial flushing, nausea, vomiting, and low blood pressure.
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