Drug Interactions With Candesartan
People who are taking or plan on taking candesartan should be aware of certain drug interactions with other medications, such as diuretics, potassium supplements, and lithium. These interactions might cause your blood pressure to decline too much or allow the levels of potassium in your body to become too high. Therefore, it is important to consult your pharmacist or healthcare provider about any candesartan drug interactions that may apply to you.
Candesartan Drug Interactions: An IntroductionCandesartan (Atacand®) can potentially interact with a number of other medications. Some of these candesartan interactions can include:
- Diuretics, such as torsemide (Demadex®), furosemide (Lasix®), hydrochlorothiazide, and others
- Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:
- Celecoxib (Celebrex®)
- Diclofenac (Cambia™, Cataflam®, Flector®, Pennsaid®, Solaraze® Gel, Voltaren®, Voltaren® Gel, Voltaren®-XR, Voltaren Ophthalmic®, Zipsor™)
- Etodolac (Lodine®, Lodine® XL)
- Ibuprofen (Motrin®, Advil®, Nuprin®)
- Indomethacin (Indocin®, Indocin SR®)
- Ketoprofen (Orudis®, Actron®, Oruvail®)
- Ketorolac (Sprix™, Toradol®)
- Meloxicam (Mobic®)
- Nabumetone (Relafen®)
- Naproxen (Naprosyn®) or naproxen sodium (Aleve®, Anaprox®, Naprelan®)
- Oxaprozin (Daypro®)
- Piroxicam (Feldene®)
- Others (see List of NSAIDs for a more complete list of these medications)
- Potassium supplements
- Potassium-sparing diuretics, such as spironolactone (Aldactone®), triamterene (Dyrenium®), and amiloride (Midamor®), among others
- Lithium (Eskalith®, Lithane®, Lithonate®, Lithotabs®).
When taking candesartan with a diuretic, your blood pressure may decrease too much. This is more likely to occur when candesartan is first started. In order to decrease the chances of this interaction, your healthcare provider may change the dosages of either medicine, start you on a lower dose of candesartan, and/or monitor you more closely.
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Candesartan can interact with NSAIDs in several ways. The combination could cause your blood pressure to increase or may cause swelling (edema), especially if you have congestive heart failure (CHF). If you are elderly, have kidney disease or kidney failure, or are taking a diuretic ("water pill") or are dehydrated, taking NSAIDs and candesartan together may cause kidney failure. Talk to your healthcare provider about this potential drug interaction before taking these medications together.
If you are taking a potassium supplement and candesartan, the levels of potassium in your blood may become too high. This can cause serious problems. For your particular situation, talk to your healthcare provider about using potassium and candesartan together.