Drug Interactions With Bumetanide
Bumetanide Interactions Explained
The following sections explain in detail the potentially negative interactions that can occur when bumetanide is combined with any of the drugs listed above.
Bumetanide should not be combined with aminoglycoside antibiotics unless absolutely necessary. Taking these two medications together can increase the chance of permanent hearing loss.
Blood Pressure Medicines
When taking bumetanide with a medication for high blood pressure, your blood pressure may decrease too much. In order to minimize the chances of this bumetanide drug interaction, your healthcare provider may monitor you more closely and/or adjust the dose of either medicine.
Taking bumetanide with corticosteroids may increase your risk of low potassium levels (hypokalemia). Your healthcare provider should check your potassium levels and may need to take steps to correct these levels to prevent this interaction from occurring.
Bumetanide should be used carefully in people taking digoxin. It can cause low potassium levels (hypokalemia), which can be especially dangerous for people taking digoxin.
Taking bumetanide with lithium may increase the level of lithium in your blood, which may increase your chance of side effects. People are generally not advised to take lithium with diuretics, including bumetanide. Your healthcare provider may need to monitor your lithium level more closely and/or adjust your lithium dose to prevent this interaction from occuring if the two medications must be taken together.
Nonsteroidal Anti-Inflammatory Drugs
Taking bumetanide with NSAIDs can make bumetanide less effective and may increase your risk of side effects. Your healthcare provider may need to increase your dose of bumetanide or may suggest an alternative to NSAIDs to prevent this drug interaction from occurring.