Warnings and Precautions With Amiloride

Before starting a new drug, it's important to be aware of its warnings and precautions. With amiloride, for example, a person may develop high potassium levels, which can be very dangerous. Also, amiloride should be avoided by anyone who is allergic to any component of the drug. Warnings and precautions with amiloride also extend to people with kidney or liver disease or diabetes.

Amiloride: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking amiloride (Midamor®) if you have:
  • Liver disease, including cirrhosis
  • Kidney disease or kidney failure
  • Diabetes
  • Fluid or electrolyte problems
  • Any allergies, including allergies to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or trying to become pregnant
  • Breastfeeding.
Tell your healthcare provider about all the medicines you are currently taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Warnings and Precautions With Amiloride

Warnings and precautions to be aware of prior to taking amiloride include the following:
  • Amiloride can cause high potassium levels (hyperkalemia). If you notice any symptoms of a possible electrolyte imbalance, contact your healthcare provider right away. These symptoms may include:
o Abnormal sensations, such as burning, tingling, or pricking
o Muscle weakness
o Low heart rate (bradycardia).
Hyperkalemia can be very dangerous. Because symptoms are not always present, your healthcare provider should measure your potassium levels regularly using a simple blood test.
  • In general, people with diabetes should not take amiloride, as they may be at higher risk for high potassium levels.
  • Amiloride should be started cautiously in people with liver disease, as it may increase the risk of hepatic encephalopathy (a brain problem in people with liver disease).
  • Do not use salt substitutes while taking amiloride. Salt substitutes usually contain potassium, and combining them with amiloride can increase the risk of high potassium levels in your blood (hyperkalemia). Herb-type salt substitutes that do not contain potassium are okay to use.
  • Several medicines can interact with amiloride (see Drug Interactions With Amiloride).
  • Amiloride is a considered a pregnancy Category B medication. This means that it may be safe to use during pregnancy, although the full risks are not known. Talk to your healthcare provider about the risks and benefits of using the drug while pregnant (see Amiloride and Pregnancy).
  • It is not known if amiloride passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking it (see Amiloride and Breastfeeding).
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