Drug Interactions With Amiloride

Amiloride Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when amiloride is combined with any of the drugs listed above.
 
ACE Inhibitors
Combining amiloride with ACE inhibitors can increase the risk of high potassium levels in your blood (hyperkalemia). Your healthcare provider should check your potassium levels regularly during treatment.
 
Angiotensin II Receptor Blockers
Taking amiloride with ARBs can increase the risk of high potassium levels in your blood (hyperkalemia). Your healthcare provider should check your potassium levels regularly during treatment.
 
Cyclosporine
Combining amiloride with cyclosporine can increase the risk of high potassium levels in your blood (hyperkalemia). Your healthcare provider should check your potassium levels regularly during treatment.
 
Digoxin
Amiloride should be used with caution in people taking digoxin. It can cause high potassium levels (hyperkalemia), which can be especially dangerous for people taking digoxin.
 
Lithium
Taking amiloride with lithium may increase the level of lithium in your blood, possibly increasing your chance of side effects. Lithium is usually not recommended for people taking diuretics, including amiloride. Depending on your individual situation, your healthcare provider may need to monitor your lithium level more closely and/or change your lithium dose.
 
Nonsteroidal Anti-Inflammatory Drugs
Taking amiloride with NSAIDs can make amiloride less effective and may increase your risk of side effects. Your healthcare provider may need to increase your dose of amiloride or may suggest an alternative to NSAIDs to prevent drug interactions from occurring.
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