Amiloride is a drug used to treat high blood pressure and fluid retention. It is usually used in combination with other diuretic medications, especially ones that are prone to causing low potassium levels. The drug comes in tablet form, and is generally taken once a day. Possible side effects of amiloride include headache, loss of appetite, and nausea.
What Is Amiloride?Amiloride (Midamor®) is a prescription medicine that is used as a diuretic for high blood pressure and fluid retention. It is known as a "potassium-sparing" diuretic.
Who Makes Amiloride?Brand-name amiloride was originally made by Merck, but is no longer being made. Generic amiloride is still available and is made by a few different manufacturers.
- Controlling high blood pressure (hypertension)
- Treating water retention (edema) associated with congestive heart failure (CHF).
In general, amiloride should be used in combination with other diuretic medications.
How Does It Work?Amiloride is a diuretic, which is commonly referred to as a "water pill." While most diuretics can cause low potassium levels in the blood (hypokalemia), amiloride is a "potassium-sparing" diuretic, meaning that it can actually increase potassium levels in the blood. It is especially helpful when used in combination with certain other diuretics, as it can help correct electrolyte imbalances caused by these particular medications.
Amiloride works by increasing the amount of salt and water the kidneys remove from the blood. This extra salt and water is then passed out through the urine. By increasing the amount of water removed from the blood, it causes a decrease in blood volume. Because of this effect, the drug can lower blood pressure and can also help with water retention.
When used alone, amiloride is a weak diuretic and is not very effective for treating high blood pressure. It is usually used in combination with other diuretic medications, especially ones that are prone to causing low potassium levels.