Drug Interactions With Amiloride-HCTZ

When certain medications are combined, there is a possibility for negative drug interactions. With amiloride-HCTZ, these interactions can lead to high potassium levels, low blood pressure, and decreased effectiveness. Alcohol, Celebrex, and Luminal are among the substances that can interact with amiloride-HCTZ. In order to reduce the risk of drug interactions with amiloride-HCTZ, your healthcare provider may monitor you more closely and adjust your dosages.

Drug Interactions With Amiloride-HCTZ: An Overview

 Amiloride-HCTZ (Moduretic®) can potentially interact with a number of other medicines. Some of the medications that can cause amiloride-HCTZ drug interactions include:
 
  • ACE inhibitors, including:

 

 

  • Alcohol 
  • Angiotensin II receptor blockers (ARBs), such as:

 

  
  • Barbiturates, including:

 

    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)

 

 

 

  • Potassium-containing products, such as:

 

    • Potassium chloride (K-Dur®, Klor-Con®, Micro-K®)
    • Potassium citrate (Urocit-K®, Polycitra-K®)
    • Potassium gluconate
    • Potassium phosphate (Neutra-Phos-K®, K-Phos®)
    • Salt substitutes (used to flavor food)

 

 
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD
 
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