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Drug Interactions With Amiloride-HCTZ
from eMedTV.comCholestyramine
Cholestyramine can decrease the absorption of amiloride-HCTZ into your blood, perhaps making it less effective. In order to avoid this interaction, it is usually best to take these medications at different times of the day.
Cyclosporine
Combining amiloride-HCTZ with cyclosporine can increase the risk of high potassium levels in your blood (hyperkalemia). Your healthcare provider should check your potassium levels regularly during treatment if you are taking these medications together.
Diabetes Medications
Since taking amiloride-HCTZ may increase your blood sugar, your healthcare provider may need to adjust your dose of diabetes medications (including insulin and oral diabetes medicines).
Digoxin
Amiloride-HCTZ should be used with caution in people taking digoxin. It can cause high potassium levels (hyperkalemia), which can be especially dangerous for people taking digoxin.
Lithium
Taking amiloride-HCTZ with lithium may increase the level of lithium in your blood, possibly increasing your risk of side effects. In general, people taking diuretics, including amiloride-HCTZ, are not advised to take lithium. Depending on your situation, your healthcare provider may need to monitor your lithium level more closely and/or change your lithium dose.
Narcotics
Combining amiloride-HCTZ with a narcotic can increase your risk of low blood pressure, especially when sitting or standing up suddenly. Talk to your healthcare provider about taking these medications together.
Nonsteroidal Anti-Inflammatory Drugs
Taking amiloride-HCTZ with NSAIDs can make amiloride-HCTZ less effective and may increase your risk of side effects. Your healthcare provider may need to increase your dose of amiloride-HCTZ or may suggest an alternative to NSAIDs to prevent this interaction from occurring.
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD