Aldactone Interactions Explained
The following sections explain in detail the potentially negative interactions that can occur when
Aldactone is combined with any of the drugs listed above.
ACE Inhibitors
Combining Aldactone with ACE inhibitors can increase your risk of high potassium levels in your blood (hyperkalemia). Your healthcare provider should check your potassium levels regularly.
Alcohol
Drinking alcohol while taking Aldactone can increase your risk of low
blood pressure, especially when sitting or standing up suddenly. Talk to your healthcare provider about combining alcohol with Aldactone.
Amiloride (Midamor) or Amiloride-HCTZ (Moduretic)
Aldactone should not be taken with
amiloride or
amiloride-HCTZ. Taking these two medications together increases your risk of high potassium levels (hyperkalemia).
Angiotensin II Receptor Blockers (ARBs)
Combining Aldactone with ARBs can increase your risk of high potassium levels in your blood (hyperkalemia). Your healthcare provider should check your potassium levels regularly.
Barbiturates
Taking Aldactone with a barbiturate can increase your risk of low blood pressure, especially when sitting or standing up suddenly. Talk to your healthcare provider before using barbiturates with Aldactone.
Other Blood Pressure Medicine
When taking Aldactone with another
high blood pressure medication, your blood pressure may decrease too much. In order to decrease the chances of this interaction, your healthcare provider may monitor you more closely and change the dose of either medicine.
Digoxin (Digitek, Lanoxin)
Aldactone should be used carefully in people taking digoxin, as Aldactone can cause high potassium levels (hyperkalemia), which can be especially dangerous for people taking digoxin. Aldactone can also increase the level of digoxin in your blood.
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