Aldactazide Drug Interactions

Cholestyramine
Cases of hyperkalemic metabolic acidosis (a potentially dangerous electrolyte and acid imbalance) have been reported in people taking cholestyramine with spironolactone, one of the active ingredients in Aldactazide. Check with your healthcare provider before combining these medications.
 
Diabetes Medications
Since taking Aldactazide may increase your blood sugar, your healthcare provider may need to adjust your dose of diabetes medications (including insulin and oral diabetes medicines).
 
Digoxin (Digitek, Lanoxin)
Aldactazide should be used with caution in people taking digoxin. It can cause high potassium levels (hyperkalemia) or low potassium levels (hypokalemia), both of which can be especially dangerous for people taking digoxin. Aldactazide can also increase the level of digoxin in your blood.
 
Eplerenone (Inspra)
Aldactazide should not be combined with eplerenone, due to the high risk for dangerously high blood potassium levels (hyperkalemia).
 
Heparin
Combining Aldactazide with heparin or low molecular weight heparin medications can increase the risk of high potassium levels in your blood (hyperkalemia). Your healthcare provider should check your potassium levels regularly if you are taking both of these medications.
 
Lithium (Eskalith, Lithobid)
Taking Aldactazide with lithium may increase the level of lithium in your blood, possibly increasing your chance of side effects. Lithium is usually not recommended to be taken with diuretics, including Aldactazide. Your healthcare provider may need to monitor your lithium level more closely and change your lithium dose, however, if you are taking both of these medications.
 
Narcotics
Taking Aldactazide with a narcotic can increase your risk of low blood pressure, especially when sitting or standing up suddenly. Talk to your healthcare provider about combining narcotics with Aldactazide.
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Aldactazide Drug Information

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